By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins
ABC Proteins is an in-depth, up to date research of all that's recognized concerning the topic to this point. It discusses and compares evolution, biology and mechanism of motion of all identified ABC proteins, together with the 1st structural stories in addition to scientific implications. it will likely be worthwhile to a person attempting to remain abreast of the newest findings. This ebook is bound to turn into a vintage and should frequently be up to date. Key positive aspects* Phylogeny and Evoloution of ABC Transporters* primary points of the Mechanism of motion of ABC Transporters* Prokaryote ABC Transporters* Non-Mammalian Transporters* Multidrug Transporters* ABC Transporters, Physiological Roles and Human illness* complete colour all through
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Additional info for ABC Proteins: From Bacteria to Man
The BAI subfamily involved in bacteriocin immunity Immunity towards bacteriocins such as lacticin RM, pediocin A and butyrivibriocin AR10 is conferred by transporters composed of one ABC and one IM. These bacteriocins are synthesized by peptide synthases, similar to the enzymes that produce peptide antibiotics. , 1999). The LAI subfamily of lantibiotic immunity systems The gene clusters determining the biosynthesis, modification and export of lantibiotics also contain genes involved in self immunity (Otto and Gotz, 2001).
T. M. (1989) Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family of ATP-binding proteins. J. Bacteriol. 171, 1932–1941. , Loncle, V. and El Solh, N. (1992) Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics. Gene 117, 45–51. , et al. (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277, 1805–1807. , Romano-Spica, V.
And Bouige, P. (2001) The ABC of ABCs: a phylogenetic and functional classification of ABC systems in living organisms. Res. Microbiol. 152, 211–229. T. , Jr (1999) The Escherichia coli ABC transporters: an update. Mol. Microbiol. 32, 887–889. , Oudega, B. and Luirink, J. (1999) Molecular characterization of Escherichia coli FtsE and FtsX. Mol. Microbiol. 31, 983–993. Decottignies, A. and Goffeau, A. (1997) Complete inventory of the yeast ABC proteins. Nat. Genet. 15, 137–145. C. and Poolman, B.