Download Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis PDF

By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between quite a few human pathogenic microorganisms akin to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as some of the most vital medical demanding situations of this century. elevated common information and worry of those pathogens skill there's a becoming call for for learn to take on the specter of multidrug resistance. Documenting the most recent learn within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key parts: molecular genetics and platforms microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.

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The number was 37 and was part of a continuous drop since 1997. 6. , 2010). 1). In 2002, there were 89 new drugs approved by the FDA but none was an antibiotic. Of the 74 new therapeutic agents approved by the FDA in 2007, only two were antibiotics. Of 2700 compounds in development in 2008, only 50 were antibacterials and, of these, only ten were from large pharmaceutical companies (Carlson, 2009). e. g. if they are ribosomal or part of a nascent peptidoglycan); and (iii) chemical libraries lack the molecular complexity of natural antibiotics.

2001) Realism in drug discovery – could Cassandra be right? Nature Biotechnology 19, 1099–1100. Hu, C. and Zou, Y. (2009) Mutilins derivatives: from veterinary to human-used antibiotics. Mini Reviews in Medicinal Chemistry 12, 1397–1406. S. R. (2010) Stable synthetic cationic bacteriochlorins as selective antimicrobial photosensitizers. Antimicrobial Agents and Chemotherapy 54, 3834–3841. , Schroeder, S. H. (2003) Structure–activity relationship in the oxazolidinone–quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.

D. (2011) Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology 7, 348–350. B. R. (2004) Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infection and Immunity 72, 3628–3633. R. P. (2011) Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against Grampositive pathogenic bacteria PLoS One 6, e18127. Finlay, B. and Falkow, S. (1997) Common themes in microbial pathogenicity revisited.

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