By George Tegos, Eleftherios Mylonakis
Drug resistance is expanding between quite a few human pathogenic microorganisms akin to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as some of the most vital medical demanding situations of this century. elevated common information and worry of those pathogens skill there's a becoming call for for learn to take on the specter of multidrug resistance. Documenting the most recent learn within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key parts: molecular genetics and platforms microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and lightweight- and nano-based applied sciences.
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Extra resources for Antimicrobial drug discovery : emerging strategies
The number was 37 and was part of a continuous drop since 1997. 6. , 2010). 1). In 2002, there were 89 new drugs approved by the FDA but none was an antibiotic. Of the 74 new therapeutic agents approved by the FDA in 2007, only two were antibiotics. Of 2700 compounds in development in 2008, only 50 were antibacterials and, of these, only ten were from large pharmaceutical companies (Carlson, 2009). e. g. if they are ribosomal or part of a nascent peptidoglycan); and (iii) chemical libraries lack the molecular complexity of natural antibiotics.
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