Download Biology of Growth Factors: Molecular Biology, Oncogenes, by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. PDF

By Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)

Growth elements are elaborated to manage the expansion of cells in such physiological strategies as wound therapeutic, tissue regeneration and the immune reaction. irregular construction of those development elements, their receptors or intracellular med!ators in their motion could lead to ailment states together with oncogenesis. This quantity will specialise in interesting advancements in defining the best molecular lesions that let the conversion of managed proliferative signs to neoplasia, at the attainable involvement of progress components within the improvement of blood vessel illnesses as noticeable in diabetes and atherosclerosis, at the altered immune surveillance that ends up in autoimmunity and at the basic mechanisms in which development elements sign their objective cells. we predict that the contents of this quantity might help advertise figuring out of the position of those primary organic techniques and their changes in a large choice of sickness states and stimulate new investi­ gations during this vital sector of biomedical study. The Editors v CONTENTS views at the keep an eye on OF progress AND DIFFERENTIATION views at the Biology of development components . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived progress issue- Its function in well-being and affliction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine R. Ross and E. W. Raines Molecular and Developmental Biology features of Fibroblast development issue. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical houses of Human Angiogenin. . . . . . . . . . forty-one B. L. Vallee and J. F. Riordan progress issue - ONCOGENE RELATIONSHIPS constitution - functionality Relationships in mobile and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . fifty five T. Pawson. P. Greer, M. Moran, K.

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Additional info for Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

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Since it seemed likely that this molecule would be active at very low concentrations, the presence of large amounts of the protein in the growth medium would only cause problems. We therefore used a procedure in which the HT-29 cells were cultured and maintained in a serum-free and exogenous protein-free, defined growth medium. While the cells do not proliferate under these conditions they actively secrete an angiogenic molecule which we have called angiogenin. All procedures for isolation of angiogenic substances require an appropriate bioassay.

In the case of FGF, partial sequence homology with the predicted product of Int-2, a potential oncogene implicated in virally induced mammary cancer (Dickson et al, 1984) has been reported (Dickson and Peter, 1987). Basic FGF seems to have been extremely well conserved through evolution. , 1986b). Avian bFGF and bovine bFGF have the same amino acid composition and avian bFGF cross-reacts on an equimolar basis with bovine bFGF in an RIA using rabbit anti-bFGF polyclonal antibodies. erved. ,1987).

Fertilization results in a subdivision of the vegetal half into a dorsal-vegetal and a ventro-vegetal region. Mesoderm is then induced from the animal hemisphere by signal(s) originating from the vegetal region of the egg (Nieuwkoop, 1969; Slack, 1983). This induction is an instructive phenomenon that suppresses epidermal differentiation of cells from the animal pole, and directs them instead to differentiate into mesodermal cells. Signal(s) originating from the dorsal-vegetal region lead to the formation of dorsal-type mesoderm, mostly consisting of notochord and somites, while signal(s) originating from the ventro-vegetal region lead to the formation of ventral-type mesoderm, consisting primarily of blood cells, mesenchyme, and mesothelium.

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