Download Current Topics in Developmental Biology, Vol. 33 by Roger A. Pedersen, Gerald P. Schatten PDF

By Roger A. Pedersen, Gerald P. Schatten

This quantity keeps the customized of addressing developmental mechanisms in various experimental structures via providing well timed experiences and incisive research of key learn in developmental biology. The conceptual series of themes starts with mobile cycle rules in the course of improvement and differentiation, maintains with the function of the epididymis and with sperm pageant, gastrulation, and embryonic stem cells, and concludes with issues of differentation in muscle cells and neurons. This quantity not just is effective to researchers on the vanguard of animal improvement, but in addition is a pleasant advent to scholars and pros who wish an creation to mobile and molecular mechanisms of improvement.

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SEM-5 was the founding member of the SH3/SH2/SH3 adapter family, which now includes Grb2 and Drk as well. By analogy with Grb2 and Drk, the likely function of SEM-5is to recruit a guanine nucleotide exchange factor to the activated LET-23 protein and bring about Ras activation. The GNEF has not yet been identified, but its presumed target, the Ras-like protein LET-60, has. , 1990; Han et a l . , 1990; Han and Sternberg, 1990). let-60 ras gain of function and dominant negative alleles have also been identified (Beitel et a l .

It is possible that the collateral signaling pathways shown in Fig. 5 are not present in Drosophilu and C. efegans. Even if the collateral pathways are present, it is still possible that R7 induction and vulval induction rely unusually heavily on the MAP kinase leg of receptor tyrosine kinase signaling, since mutant screens tend to focus selectively on signaling processes with little redundancy built into them. However, it is becoming increasingly clear that MAP kinase activation is just as central to receptor tyrosine kinase signaling in mitogenesis as it is to R7 induction and vulval induction.

As yet it is unclear how Cdc37 affects Sev signaling. Also, the E(sev)lA locus is allelic to corkscrew (csw), which encodes an SH2 domaincontaining tyrosine phosphatase related to mammalian Syp/SH-PTP2. corkscrew was originally identified as a member of the torso pathway and is required for development of terminal structures (Perkins et a f . , 1992). Corkscrew acts as a positive downstream effector of Torso. Exactly why this phosphotyrosine phosphatase mediates-rather than opposes-signaling from the Torso and Sevenless receptor tyrosine kinases is unclear.

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