By Michael T. Lotze, Angus W. Thomson
Dendritic Cells, second variation is the recent variation of the tremendous profitable publication released in 1998. With the amount of literature on dendritic cells doubling each year, it's virtually very unlikely to take care of. This ebook presents the main updated synthesis of the literature, written via the superior authors. it truly is crucial studying for any scientist operating in immunology, mobilephone biology, infectious ailments, melanoma, transplantation, genetic engineering, or the pharmaceutical/biotechnology undefined. * a wholly new part on DC biology is incorporated during this version. additionally new to this variation are chapters on:* Imaging* interplay of dendritic cells with viruses* Dendritic cells and dendrikines, chemokines and the endothelium* Molecules expressed in dendritic cells* function of dendritic cells in wound therapeutic and atherosclerosis* supply of apoptotic our bodies* Genetic engineering of dendritic cells* Imaging* functional facets of scientific protocol improvement
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Extra resources for Dendritic Cells: Biology and Clinical Applications
1999) The latter antigen is expressed on the thymic cells but not on those in peripheral blood and tonsil. 2 Phenotype of CD3ϪCD4ϩCD8Ϫ human thymic subpopulations and DC precursors from tonsil and peripheral blood 17 present on all thymic cells but only on subsets of peripheral blood and tonsillar CD3ϪCD4ϩ cells. These differences in expression of CD2, CD5 and CD7 could be caused by the different microenvironments. It is, however, also possible that thymic and peripheral pDCs represent different subsets.
L. and Shortman, K. (1996). J. Exp. Med. 184, 903–911. ORIGIN AND MOLECULAR BIOLOGY OF DENDRITIC CELLS 03 Liu 0791 16/7/01 10:13 am Page 21 C H A P T E R 3 T-cell activation and polarization by dendritic cells Yong-Jun Liu, Vassili Soumelis and Nori Kadowaki DNAX Research Institute, Palo Alto, California, USA If a man loses pace with his companions, perhaps it is because he hears a different drummer. Let him step to the music in which he hears, however measured, or far away. , 1997). The questions are: (1) Are there distinct types of DCs?
This was directly shown by Brocker and collaborators. They have generated a transgenic mouse model in which gene expression was targeted to DC using the CD11c promoter. , 1997). In contrast, when DCs expressed I-E in a class II-deficient background, positive selection of CD4ϩ T cells could not be observed. Thus negative, but not positive, selection events can be induced by DCs in vivo. The other non-T cells found in the thymus are NK and B cells and macrophages. Macrophages T cells mostly develop in the thymus.