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By M. Esteller

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Smiraglia D. , Rush L. , Robertson G. , Wright F. , Feramisco J. , Lang J. , Schuller D. , Bloomfield C. , Caligiuri M. , Petrelli N. , O'Dorisio M. , Held W. , Cavenee W. K. and Plass C. Aberrant CpGisland methylation has non-random and tumour-type-specific patterns. Nat Genet, 2000; 24: 132-138. 41. , Baylin S. B. and Herman J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res, 1999; 59: 67-70. 41 42.

37. Danam R. , Howell S. , Remack J. , Brent T. P. Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. Int J Oncol, 2001; 18:1187-1193. 38. , Esteller M. The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis, 2002; 23:1103-1109. 39. Turner B. M. Cellular memory and the histone code. Cell, 2002; 111:285-291. 40. , Bachman K. , Park B. , Jair K. , Yen R. , Schuebel K. , Feinberg A. , Kinzler K.

Baylin S. , Herman J. G. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res, 2000; 60:2368-2371. 36. G. A gene hypermethylation profile of human cancer. Cancer Res, 2001; 61:3225-3229. 37. Danam R. , Howell S. , Remack J. , Brent T. P. Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. Int J Oncol, 2001; 18:1187-1193.

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