Download Dopamine in the Pathophysiology and Treatment of by Shitij Kapur, Yves Lecrubier PDF

By Shitij Kapur, Yves Lecrubier

New findings have surfaced at the position of dopamine within the therapy of schizophrenia. This quantity provides a overview of these findings, first explaining the etiology of the ailment after which profiling the motion of antipsychotic medicinal drugs. the writer provides all facets of the pathophysiology and remedy of schizophrenia, together with the imaging of dopamine structures within the mind. The textual content identifies genetic polymorphisms that have an effect on dopaminergic neurotransmission and their attainable impression on familial sorts of schizophrenia. It additionally explores the neurophysiological and neurochemical experiences of dopaminergic functionality.

Show description

Read Online or Download Dopamine in the Pathophysiology and Treatment of Schizophrenia: New Findings PDF

Best mathematicsematical physics books

AB Variant GM2-Gangliosidosis - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers

In March 2001, the nationwide Institutes of healthiness issued the next caution: "The variety of sites supplying health-related assets grows each day. Many websites supply necessary details, whereas others could have details that's unreliable or deceptive. " additionally, as a result of fast raise in Internet-based details, many hours will be wasted looking, choosing, and printing.

Dopamine in the Pathophysiology and Treatment of Schizophrenia: New Findings

New findings have surfaced at the function of dopamine within the therapy of schizophrenia. This quantity offers a overview of these findings, first explaining the etiology of the ailment after which profiling the motion of antipsychotic medicines. the writer offers all elements of the pathophysiology and remedy of schizophrenia, together with the imaging of dopamine structures within the mind.

Additional resources for Dopamine in the Pathophysiology and Treatment of Schizophrenia: New Findings

Sample text

Am J Psychiatry 148:1474–86. De Keyser J, Ebinger G, Vauquelin G. (1989) Evidence for a widespread dopaminergic innervation of the human cerebral neocortex. Neurosci Lett 104:281–5. Dearry A, Gingrich JA, Falardeau P et al. (1990) Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature 347:72–6. DeLong MR, Crutcher MD, Georgopoulos AP. (1985) Primate globus pallidus and subthalamic nucleus: functional organization. J Neurophysiol 53:530–43. Deutch A, Clark WA, Roth RH (1990) Prefrontal cortical dopamine depletion enhances the responsiveness of the mesolimbic dopamine neurons to stress.

Green MF. (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153:321–30. Guo N, Hwang D, Abdellhadi S et al. (2001) The effect of chronic DA depletion on D1 ligand binding in rodent brain. Soc Neurosci Abst:27. Haber SN, Fudge JL. (1997) The primate substantia nigra and VTA: Integrative circuitry and function. Crit Rev Neurobiol 11:323–42. Haber SN, Fudge JL, McFarland NR. (2000) Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum.

Mrzljak L, Bergson C, Pappy M et al. (1996) Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 381:245–8. Mukherjee J, Yang ZY, Das MK, Brown T. (1995) Fluorinated benzamide neuroleptics-III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3dimethoxybenzamide as an improved dopamine D-2 receptor tracer. Nucl Med Biol 22:283–96. Murray A, Ryoo HL, Gurevich E, Joyce JN. (1994) Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesofrontal regions of human forebrain.

Download PDF sample

Rated 4.12 of 5 – based on 26 votes