Download Drug Metabolism: Current Concepts by Mino R. Caira, Corina Ionescu PDF

By Mino R. Caira, Corina Ionescu

Drug Metabolism: present Concepts

Corina Ionescu and Mino R Caira

Drug Metabolism: present recommendations offers a entire knowing of the methods that happen following ingestion of a medicinal agent or xenobiotic, with an emphasis at the an important function of metabolism (biotransformation). How a legitimate wisdom of those phenomena is included into the layout of powerful new drug applicants can be defined. The ordinary textual content makes a speciality of thoughts instead of extraneous information and is supported through many illustrated examples of biotransformations in addition to common references to present severe studies and articles highlighting the character of study goals during this bright region of medicinal improvement. the ultimate subject on options for drug layout is determined by the historical past supplied by way of the remainder of the book.

The e-book contains chapters on

ADME (drug absorption, distribution, metabolism and removal)

Pathways of biotransformation (Phase I and section II metabolic reactions)

Enzymatic platforms fascinated by biotransformation

Induction and inhibition of drug-metabolising enzymes

Factors that impression drug biotransformation

The position of pharmacogenetics

Drug-drug interactions and antagonistic reactions

Strategies for drug layout.

This e-book is perfect as a sophisticated textual content for classes in drug metabolism for college kids of medication, pharmacy, pharmacology, biochemistry; and for classes in drug layout and drug supply for college kids of medicinal chemistry. it's also acceptable for pro seminars or classes that relate to the destiny of a drug within the physique, drug interactions, opposed reactions and drug design.

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Additional info for Drug Metabolism: Current Concepts

Example text

2000. Drug Absorption, Action, and Disposition. In: Gennaro AR, editor. Remington: The Science and Practice of Pharmacy, 20th ed. Philadelphia: Lippincott Williams&Wilkins, pp 1098-1126. 9. Ying J, Zhiqiang J. 2003. Advances on oral mucosal drug delivery system. Zhongguo Shenghua Yaowu Zazhi 24:150-152. 10. Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol To 3: 346-358. 38 Chapter 1 11. Lennernas H. 2003. Intestinal drug absorption and bioavailability: Beyond involvement of single transport function.

Mechanisms of Drug Action (Pharmacodynamics). In: Radojicic R, Goodgame F, editors. A Textbook of Clinical Pharmacology, 4th ed. , pp 8-16. 50. Ross EM, Kenakin TP. 2001. Pharmacodynamics: Mechanism of Drug Action and the Relationship Between Drug Concentration and Effect. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman&Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), pp 31-44. 51. Gibson GG, Skett P. 1994.

The ability of ten human liver microsomes to metabolise this polychlorinated compound was assessed. 2. Propranolol is first oxidised to 4hydroxypropranolol, which then undergoes sequential metabolism to 4-hydroxypropranolol glucuronide [11]. Other biotransformation reactions of propranolol will be presented later. 3) [9]. 4). 4 Parallel biotransformation pathways of dextromethorphan Reversible metabolism may occur when a metabolite or biotransformation product and the parent drug undergo interconversion.

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