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By Ezio Ghigo

Ghrelin is a 28-amino acid acylated peptide predominantly produced by way of the tummy. It monitors powerful GH-releasing job mediated by way of the hypothalamus-pituitary GH secretagogue (GHS)-receptors particular for artificial GHS. Ghrelin additionally acts on different principal and peripheral receptors and permits different activities together with: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic features; metabolic; cardiovascular job; and anti-proliferative results. This quantity goals to spotlight the impression and serve as of the hormone ghrelin and supply perception to neuroendocrinologies and researchers drawn to its molecular and scientific relevance.

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Nature. 1999; 402:656-60. Arvat E‚ Maccario M‚ Di Vito L‚ et al. Endocrine activities of ghrelin‚ a natural growth hormone secretagogue (GHS)‚ in humans: comparison and interactions with hexarelin‚ a nonnatural peptidyl GHS. J Clin Endocrinol Metab. 2001; 86:1169-74. Banks WA‚ Tschop M‚ Robinson SM‚ Heiman ML. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther. 2002; 302:822-7. Bednarek MA‚ Feighner SD‚ Pong S-S‚ et al.

Growth hormone-releasing peptides and their analogs. Front Neuroendocrinol. 1998; 19:47-72. 5. Codd EE‚ Yellin T‚ Walker RF. Binding of growth hormone-releasing hormone and enkephalin-derived growth hormone releasing peptides to mu and delta opioid receptors in forebrain of rat. Neuropharmacology. 1988; 27:1019-25. 6. Sethumadavan K‚ Veeraragavan K‚ Bowers CY. Demonstration and characterization of the specific binding of growth hormone-releasing peptide to rat anterior pituitary and hypothalamus.

This deletion results from the use of the CAG codon, which encodes glutamine 14 as well as acts as a splicing signal. Thus, two types of active ghrelin peptide are produced in rat stomach, ghrelin and (Figure 2-3). However, is only present in low amounts in the stomach and full-length ghrelin is the major active form. Chapter 2 22 7. 1 Bullfrog ghrelin Amphibian ghrelin has been identified from the stomach of bullfrog (Figure 2-6) (21). The three forms of ghrelin identified in bullfrog stomach, each comprising 27 or 28 amino acids, possess 29% sequence identity with human ghrelin.

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