By de Waal Malefyt R.
IL-10 interacts with its tetrameric receptor complicated together with IL-10R♂ and IL-10R♀ chains leading to the phosphorylation and activation of JAK1 and TYK2 kinases, which in flip phosphorylate tyrosine residues within the intracytoplasmic elements of the IL-10R♂ chains that shape docking websites for STAT3. Binding of STAT3 leads to phosphorylation through JAK1 and TYK2 kinases, homo- or heterodimerization and translocation to the nucleus the place it binds to the promoters of IL-10-responsive genes akin to the FcRI and prompts transcription. All IL-10-mediated responses are depending on activation of STAT3, however the anti inflammatory activities of IL-10 require extra sequences within the distal intracytoplasmic a part of the IL-10R♂ chain.
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2008. Retinyl ester formation by lecithin:retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem 283:5611–5621. Konige M, Wang H, Sztalryd C. 2013. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim Biophys Acta 1842(3)393–401. Kos K, Wong S, Tan BK, et al. 2011. Human RBP4 adipose tissue expression is gender specific and influenced by leptin. Clin Endocrinol 74:197–205. Kotnik P, Fischer-Posovszky P, Wabitsch M.
1999, 2005). Hence, Rbp-deficient mice are prone to developing vitamin A deficiency when subjected to insufficient dietary vitamin A intake. Since retinyl esters are very highly hydrophobic, they are, thus, incorporated into intracellular lipid droplets. The formation and degradation of intracellular lipid droplets is a highly regulated process involving lipid synthesizing and degrading enzymes and many different lipid droplet-associated proteins. , 2013). As is discussed in more detail later, the RPE retinosomes and the HSC lipid droplets are specialized lipid droplets that accumulate relatively high concentrations of retinyl esters.
Proc Natl Acad Sci USA 108:4340–4345. Berry DC, Jacobs H, Marwarha G, et al. 2013. The STRA6 receptor is essential for retinolbinding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem 288:24528–24539. Biesalski HK, Frank J, Beck SC, et al. 1999. Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am J Clin Nutr 69:931–936. Blaner WS. 2007. STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens.