Download Immunity-Based Systems: A Design Perspective by Yoshiteru Ishida PDF

By Yoshiteru Ishida

After I got here to understand Jerne's community conception at the immune process, I turned serious about the immune process as a knowledge procedure. the most seasoned­ totypes for organic details platforms were the neural platforms and the mind. notwithstanding, the immune approach is not just an attractive informa­ tion process however it could provide a layout paradigm for man made details platforms. With one of these attention, I initiated a undertaking titled "autonomous decentralized attractiveness mechanism of the immune community and its applica­ tion to dispensed details processing" in 1990 below a Grant-in-Aid for medical learn on a concern quarter ("Autonomous disbursed Systems") supported via the Ministry of schooling, technology, and tradition. throughout the undertaking, I promoted the concept that the immune method can be a prototype of self sustaining dispensed platforms. After the venture, we prepared a world workshop on immunity­ dependent platforms in 1996 at the side of the overseas convention on Multi-Agent structures held in Kyoto, Japan. lately, there were numerous foreign meetings on the topic of themes encouraged via the immune method and more and more study papers on the topic of the subject. In penning this ebook, a decade after the venture, I nonetheless think that the immune method could be a prototype, a compact yet subtle approach that nature has proven us for development synthetic details structures during this community age of the twenty-first century.

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However, the correspondence between an antigen and antibody is not one-to-one; different antigens may have cross-reactivity, meaning that they react with a common antibody. Rather than going into detail about structural differences between B-cell and T-cell receptors, we focus here on common features of the structure. Both of them consist of a variable region (V-region) and a constant region (C-region). Owing to the difference in V-region from receptor to receptor, each receptor has specificity.

If : . . Antigen .. ,.. ,.. SJ~ t,J SJ~ t,JSJ~ t,J Fig. 14. ,.. 5 The Immune System as a Self-Defining System 47 While Jerne first proposed the natural selection theory [76], Burnet extended the clonal selection theory. The CST extended by Burnet and others encompassed the "self" concept of the immune system. Although the genetic self is predetermined, the operational self is constructed by referring to the self: the self-reactive component (antibody producing B-cells) is eliminated during the developmental process.

Any disturbance can be a challenge to the system. As any component could not be free from fault, a life system cannot be free from death as long as it is alive. The component with a hundred percent reliability could not have interacted with the real world. " Entities (cells) must be so integrated that they would sacrifice themselves for the sake of the whole system (organism). For a collection of autonomous agents to be aggregated into an organism with a boundary, agents interact so intensively that any disharmonious entities (or agents) will be rejected or eliminated from the system.

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