By Duzgunes N. (ed.), Abelson J. N. (ed.), Kaplan N. O. (ed.)
Liposomes are mobile constructions made from lipid molecules. very important as a mobile version within the learn of simple biology, liposomes also are utilized in medical purposes reminiscent of drug supply and virus stories. Liposomes half E is a continuation of prior MIE Liposome volumes A, B, C and D.* probably the most hugely revered courses within the box of biochemistry on account that 1955* often consulted, and praised via researchers and reviewers alike* really a necessary ebook for someone in any box of the lifestyles sciencesAnnotationLiposomes are mobile buildings made from lipid molecules. very important as a mobile version within the examine of uncomplicated biology, liposomes also are utilized in medical functions reminiscent of drug supply and virus experiences. Liposomes half E is a continuation of past MIE Liposome volumes A, B, C and D. essentially the most hugely revered guides within the box of biochemistry because 1955
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Extra info for Liposomes Part E
At this point, the lipids should be left in a small volume of CHCl3, in a slurry-like consistency. If too much solvent is removed at this point, it will be difficult to subsequently obtain a completely dried film. The remaining solvent is removed under a high vacuum (approximately 75 cm Hg) for a minimum of 3 h, or until no solvent remains in the tube. If the starting amount of lipid is above approximately 20 mg, the application of a vacuum should result in a lipid ‘‘puff’’ rising to halfway up the test tube.
S. FDA. While liposomal systems for genetic drugs have not been developed to the same extent, several systems are available for both plasmid DNA and antisense oligonucleotides that have systemic potential. Further advances in this field are anticipated as tissue targeting and controlled drug release capabilities are included in future liposome designs. , Bally, M. , Shew, C. , and Madden, T. D. (1999). Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity.
Biochim. Biophys. Acta 1510, 152–166. Semple, S. , Klimuk, S. , Harasym, T. , and Hope, M. J. (2000). Lipid-based formulations of antisense oligonucleotides for systemic delivery applications. Methods Enzymol. 313, 322–341. , G. (1968). Phospholipid spherules (liposomes) as a model for biological membranes. J. Lipid Res. 9, 310–318. Shields, A. , Lange, L. , and Zalupski, M. M. (2001). Phase II study of liposomal doxorubicin in patients with advanced colorectal cancer. Am. J. Clin. Oncol. 24, 96–98.