By Thomas J. Anderson, William R. Miller (auth.), Robert B. Dickson, Marc E. Lippman (eds.)
The present quantity represents the fourth over a interval of 5 years in our sequence on Advances within the mobile and Molecular Biology of Breast melanoma. the 1st 3 volumes have been entitled Breast melanoma: mobile and Molecular Biology, Regulatory Mechanisms in Breast melanoma, and Genes, Oncogenes, and Hormones, respectively. all through this sequence, we have now attempted to take a huge examine state-of-the-art subject matters in easy technological know-how examine into breast melanoma. This test has led to a variety of material, together with rodent and human version platforms, oncogenes, suppressor genes, development components, hormones, tumor-host interactions, and determinants of metastases. due to the fact our final quantity, learn in breast melanoma has persevered to continue at an explosive expense. we are hoping the present quantity will give you the reader with a number of the pleasure felt by means of the editors and authors as we start to appreciate this all-too-common sickness. the 1st component to this e-book is dedicated to the elemental techniques of proli feration, differentiation, and malignant development of breast melanoma. T.l. Anderson and W.R. Miller lead off with a close description of controls on proliferation within the general human breast and in breast melanoma. This bankruptcy strongly emphasizes pathological elements. the second one bankruptcy, through M.R. Stampfer and P. Yaswen, offers a corresponding standpoint via a presentation of experiments with human mammary epithelial cells in tradition. the second one portion of the e-book emphasizes the genetic foundation for breast melanoma onset and malignant development. bankruptcy three, through M.-C. King and S.
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Extra resources for Mammary Tumorigenesis and Malignant Progression: Advances in Cellular and Molecular Biology of Breast Cancer
1990. Endocrine trcatment of breast cancer in women. Endocrine Rev 2:221-265. 80. Horwitz KB, Freidenberg GR. 1985. Growth inhibition and increase of insulin receptors in anticstrogcn-resistant T47DCO human breast canccr cells by progestins; implications for endocrine therapies. Cancer Res 45:167-173. 81. Clark JH, Peck EJ lr. 1979. Female sex steroids. Receptors and Function. Springer: Berlin, pp 99-113. 82. King RJB. 1990. Role of oestrogen and progestin in human mammary carcinogenesis. In Goldhirsch A (ed), Endocrine Therapy of Breast Cancer IV.
Hellman S, Harris lR. 1987. The appropriate breast cancer paradigm. Cancer Res 47: 339-342. 60. Tubiana M, Koscielny S. 1991. Natural history of human breast cancer: Recent data and clinical implications. Breast Cancer Res Treat 18:125-140. 61. Linell F, Rank F. 1989. Breast Cancer. Comments on Histologic Classifications with Reference to Histogenesis and Prognosis. Universitetsforlaget Dialogos: Lund, pp 18-68. 62. Anderson Tl, Battersby S. 1985. Radial scars of benign and malignant breasts: comparitive features and significance.
In terms of the development of breast cancer, the concept of transition from normal to malignant that proceeds through defined stages of hyperplasia, atypia, and noninvasive cancers, as has been observed in other organs, has been less easy to confirm. It is therefore difficult to avoid the conclusion that all cancers do not have a common pathway of origin and that there is a heterogeneity in the routes by which invasive cancers develop. If this is the case, then it can be anticipated that any associated changes in growth controls will be equally varied.