Download Mapping of nervous system diseases via MicroRNAs by Christian Barbato, Francesca Ruberti PDF

By Christian Barbato, Francesca Ruberti

In fresh years, realizing of microRNA (miRNA) biogenesis, the molecular mechanisms through which miRNAs keep watch over gene expression, and the sensible roles of miRNAs has multiplied. Mapping of fearful method ailments through MicroRNAs offers an up to date evaluation at the functionality of miRNA in neurological illnesses in addition to developments in know-how for healing modulation of miRNA activity.

MicroRNAs are small RNA molecules that control gene expression post-transcriptionally. A starting to be physique of proof means that miRNAs are dysregulated in different neurological problems. as well as reviewing common ideas and novel insights on mind functionality relating to miRNA, this e-book additionally examines the position of miRNA in:

  • Neurological diseases
  • Neurodegenerative diseases
  • Neuropsychiatric diseases
  • Neurodevelopmental diseases

The booklet additionally discusses the importance of miRNAs as diagnostic instruments, biomarkers, brokers, and goals within the detection and remedy of neurological illnesses. every one bankruptcy includes fabric relating to destiny diagnostic and healing advances.

Molecular and mobile neurobiological reports of miRNA-mediated gene silencing within the apprehensive approach have opened new frontiers for the improvement of recent diagnostic assessments and genetic remedies for neurological ailments. protecting the entire variety of suitable strategies and giving a glance into current and destiny probabilities, Mapping of fearful approach illnesses through MicroRNAs is an important state of the art reference for neurologists, neuropathologists, and researchers and practitioners in a variety of similar fields.

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Extra resources for Mapping of nervous system diseases via MicroRNAs

Sample text

Interestingly, miR-16 levels negatively correlated with depressive-like behaviors. , 2011). Uchida 30 Mapping of Nervous System Diseases via MicroRNAs et al. 1). There was no overlap in the findings of this study and the one conducted by Bai et al. However, one issue with these studies is that they each examined miRNA levels in different brain regions and tissue types. As discussed earlier, different brain regions and cell types display different miRNA profiles and so this may account for the lack of consistency in the findings to date.

53 References................................................................................................................. , 2011). Affective disorders are characterized by episodes of abnormally depressed or elated 21 22 Mapping of Nervous System Diseases via MicroRNAs mood. , 2012; Kessler and Bromet, 2013). It can be difficult to treat and is associated with increased suicide rates (Bostwick and Pankratz, 2000). , 2012). Anxiety disorders is an umbrella term for a number of disorders, including specific phobias, social phobias, posttraumatic stress disorder (PTSD), generalized anxiety disorder, panic disorder, agoraphobia, and obsessive-compulsive disorder (OCD).

Perturbations of the cholinergic system and alterations in muscarinic acetylcholine receptor levels have been implicated in mood disorders. Lithium is known to impact on the cholinergic system. Based on the findings of Zhou et al. (2009) which showed lithium-induced downregulation of let-7b, Creson et al. (2011) went on to further investigate the effects of chronic lithium treatment on let-7b and its target the presynaptic M1 muscarinic receptor (M1). They found that let-7b negatively regulates levels of M1 in vitro and that lithium significantly increases M1 levels in vivo in the frontal cortex.

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