By Gaetano Santulli
This quantity explores microRNA functionality in a wide range of human problems, supplying a medical foundation for precision drugs and customized remedies utilizing those molecules. The twenty-one chapters, all authored via internationally-renowned specialists, open with an advent contextualizing microRNA manipulation inside today’s projects in the direction of precision medication. the subsequent chapters discover the scientific position of microRNAs within the prognosis and remedy of metabolic and cardiovascular problems, targeting mitochondrial health, arterial high blood pressure, cardiovascular home improvement, cerebrovascular sickness, pulmonary high blood pressure, diabetic kidney disorder, and kidney transplantation. the following chapters speak about the significance of microRNAs within the wound therapeutic strategy and in epidermis sickness, within the pathogenesis of hypersensitivity, in human ovulation, and in an infection. The e-book concludes with chapters which define the rising position of microRNAS in doping and aspect microRNA profiling.
Read or Download microRNA: Medical Evidence: From Molecular Biology to Clinical Practice PDF
Similar basic science books
Not anything is extra complicated to the clinician new to gadget remedy than having to accommodate cardiac electrocardiograms from a tool sufferer. Pacemakers and different implantable cardiac rhythm administration units depart their “imprint” on ECGs and will considerably switch what clinicians see - or count on to determine.
Conventional examine methodologies within the human respiration approach have consistently been difficult because of their invasive nature. contemporary advances in clinical imaging and computational fluid dynamics (CFD) have speeded up this learn. This booklet compiles and info contemporary advances within the modelling of the breathing procedure for researchers, engineers, scientists, and health and wellbeing practitioners.
The most objective of this monograph is to supply an outline of calcium law in cardiac muscle cells, rather with recognize to excitation-contraction coupling and the keep watch over of cardiac contractile strength. it's my desire that this booklet might be worthwhile to scholars of the cardiovascular process and muscle in any respect diversified degrees and in numerous disciplines (such as body structure, biochemistry, pharmacology and pathophysiology).
This booklet presents a complete evaluation of contemporary nuclear magnetic resonance methods to biomedical difficulties in vivo utilizing state of the art suggestions. It devotes equivalent cognizance to the equipment and functions of NMR and addresses the opportunity of all the strategies mentioned. the amount comprises late-breaking parts akin to useful imaging, circulate imaging, bioreactor spectroscopy, and chemical shift imaging.
- Origination of Organismal Form: Beyond the Gene in Developmental and Evolutionary Biology
- Phosphodiesterase Inhibitors (Handbook of Immunopharmacology)
- Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies
- Excitation-Contraction Coupling and Cardiac Contractile Force
Additional resources for microRNA: Medical Evidence: From Molecular Biology to Clinical Practice
Therefore, miR-146a may provide an efﬁcient means to suppress glia-mediated neuroinﬂammation, although the contribution of miR-146a per se to pain caused by arthritis remains unknown. miRNAs in Visceral Pain Visceral pain arises from an enormous range of diseases associated with inﬂammation, mechanical stresses, cancers, or unknown causes. Microarray or TaqMan array analyses revealed miRNA dysregulation in colonic biopsies  and whole-blood samples  from patients with irritable bowel syndrome (IBS) and bladder biopsies from patients with bladder pain syndrome (BPS) .
MiR-182-96-183 is a miRNA cluster that includes three distinct miRNAs (miR-182, miR-96, and miR-183) located close to one another on the genome, and is possibly transcribed as a single common primary transcript. All three cluster members were highly enriched in the DRG and were downregulated in DRG neurons after spinal nerve ligation . Accordingly, miR-96 and miR-183 were shown to suppress neuropathic pain induced by traumatic peripheral nerve injury [56, 57]. 3 upregulation in the DRG after nerve injury.
Wang Z. miRNA in the regulation of ion channel/transporter expression. Compr Physiol. 2013;3:599–653. 19. Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN. Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci. 2010;30:10860–71. 20. Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, Liang DY, Clark JD. miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.