Download Microbicides for Prevention of HIV Infection by Jeremy Nuttall PDF

By Jeremy Nuttall

One of the main promising new ways for the prevention of HIV transmission, relatively for constructing nations, consists of topical, self-administered items referred to as microbicides. the advance of microbicides is a protracted and complex technique, and this quantity presents an outline of the entire severe parts, from the choice of applicable candidate molecules and their formula, preclinical and scientific checking out for safeguard and efficacy, thoughts for product registration and at last, concerns linked to product release, distribution and entry. The publication will turn out beneficial to either these operating within the box and all others who're drawn to studying extra approximately this product category, which has the aptitude to noticeably influence the way forward for this devastating epidemic.

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Paper presented at Microbicides 2010, Pittsburgh MTN (2011) MTN statement on decision to discontinue use of tenofovir gel in VOICE, a major HIV prevention study in women. org/node/3909 Neagu MR, Ziegler P, Pertel T, Strambio-De-Castillia C, Grutter C, Martinetti G, Mazzucchelli L, Grutter M, Manz MG, Luban J (2009) Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest 119:3035–3047 Nel A, Smythe S, Young K, Malcolm K, McCoy C, Rosenberg Z, Romano J (2009a) Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIVnegative women.

Cellulose derivatives like hydroxyl ethyl cellulose (HEC) and poly acrylic acid derivatives like Carbopol 974P are the most commonly used polymers due to their generally recognized as safe (GRAS) status, cost effectiveness, and safety profile. 7 % w/w HEC as the gelling agent. Another common practice in the formulation of gel products is to include preservatives to avoid bacterial growth within the product upon storage. A combination of methyl paraben and propyl paraben is one of the most widely utilized preservative systems in microbicide products currently being evaluated.

36 L. C. Rohan et al. 1 The History and Background of Polymeric Thin Films Thin polymeric films are solid dosage forms which consist of an active agent incorporated into a polymeric matrix. When applied to a mucosal surface the film disintegrates and releases the active drug agent. Oral thin films were first introduced in the 1970s. In 2001, Pfizer introduced the ListerineÒ Strip to freshen breath and by 2006, nine oral thin films were marketed worldwide. The initial thin films that were marketed were for consumer or cosmetic products.

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