By Didier Picard (auth.), Leonard P. Freedman (eds.)
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Extra resources for Molecular Biology of Steroid and Nuclear Hormone Receptors
Domain E, with moderate to low homology, is required for the binding of ligand and is called the ligand, or hormone, binding domain (LBD). However, most (> 90) members of the superfamily do not bind any known ligands, and thus are called "orphan receptors" (Mangelsdorf and Evans 1995, Enmark and Gustafsson 1996). Further studies have documented the presence of activities other than ligand binding in domain E. The purpose of this review is to summarize what is known about each of these LBD activities, with particular emphasis being devoted to the question of which of those properties are general for the superfamily members as a whole, and which are not.
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