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R. (1993) J. Pharmacol. Exp. Ther. 264, 676–682. 44. R. M. (1998) Nature (London) 391, 608–612. 45. , Marcy, A. , et al. (1995) Protein Sci. 4, 1966–1976. 46. Bode, W. & Huber, R. (1992) Eur. J. Biochem. 204, 433–451. 47. , Huber, R. & Bode, W. (1988) EMBO J. 7, 345–351. 48. , Sakakibara, S. & Katsube, Y. (1996) Biochemistry 35, 11570–11576. 49. , Deisenhofer, J. & Steigemann, W. (1974) J. Mol. Biol. 89, 73–101. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files.

1995) Science 268, 533–539. 10. , Huber, R. & Baumeister, W. (1995) Science 268, 579–581. 11. , Stachon, U. H. (1997) J. Biol. Chem. 272, 25200–25209. 12. , et al. (1998) Proc. Natl. Acad. Sci. USA 95, 12504– 12509. 13. Brunger, A. 1; A System for X-Ray Crystallography and NMR (Yale Univ. Press, New Haven, CT). 14. Turk, D. D. ; Munich). 15. A. (1978) J. Appl. Crystallogr. 15, 24–31. 16. M. & Schmidt, M. (1996) EMBO J. 15, 6887–6898. 17. , Stock, D. & Löwe, J. (1997) Biol. Chem. 378, 239–247. 18.

26. , Huber, R. & Moroder, L. (1999) Chem. Biol. 6, 197–204. 27. , Huber, R. & Moroder, L. (1999) Proc. Natl. Acad. Sci. USA 96, 5418–5422. 28. S. & Hochstrasser, M. (1999) EMBO J. 18, 3575–3585. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted.

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