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By Ronald B. Herberman

NK Cells and different normal Effector Cells studies the nation of information on NK cells and different ordinary effector mechanisms. The assurance of immune effector platforms levels from simple reports on their nature, law, and mechanisms of motion to special functional concerns resembling their function in host resistance, their modulation by means of healing intervention, and adjustments in their job in sickness.
The publication is geared up into 12 components. elements I and II learn the features of NK cells and different usual effector cells, respectively. half III makes a speciality of the phone lineage of NK and comparable effector cells, delivering facts for or opposed to T mobile lineage, for or opposed to macrophage lineage, and for or opposed to different or separate lineage. half IV offers with the genetics of usual resistance within the mouse and rat. half V provides experiences at the rules of cytotoxic job. half VI examines the specificity of ordinary effector cells, masking the character of aim telephone constructions and the character of popularity receptors in effector cells. half VII discusses the cytotoxicity by way of cultured lymphoid cells whereas half VIII turns to the mechanisms of cytotoxicity. half IX bargains with normal cell-mediated reactivity opposed to basic tumor cells and opposed to non-tumor objectives. half X examines NK phone tumors or the presence of NK cells on the web site of tumor development. half XI offers scientific reports with typical effector cells. half XII presents proof for in vivo reactivity of usual effector cells.

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Analyzed by a 12 hour single cell cytotoxicity assay. , 1979). A 12 hour assay was used. , 1982). I. Characteristics of NK Cells 11 3 ) , only LGL bound to the target cells and a high cytotoxic activity was detected, d) among pure non-LGL populations (fractions 6 and 7 ) , some lymphocytes bound to the target cells, but no cytotoxicity could be detected, e) preincubation of effector cells with IFN increased the number of NK cells among binding cells, but the number of killer cells never exceeded the frequency of LGL among binding cells· Taken together, the data indicate that LGL are the principal NK cells in peripheral blood.

Rosetting cells were 1 The experimental work described in this paper was supported by NIH grants CA 10815 and CA 20833· NK CELLS AND OTHER NATURAL EFFECTOR CELLS 39 Copyright © 1982 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0-12-341360-5 40 NK Cells and Other Natural Effector Cells TABLE I. w· x 10~"3 Ref. R. R. R. R. R. R. R. R. R. R. R. 2 a Not reported. scored and separated from non-rosetting cells on a FicollHypaque density gradient. LU for both populations were computed.

A possible d i f f e r e n t i a t i o n pathway of human NK cells. I. Characteristics of NK Cells 37 The results of our studies of adult and fetal lymphoid compartments suggest that the three distinct phenotypes may represent different stages in differentiation of HNK-1 + cells. We propose a hypothetical model of NK cell differentiation in Figure 1. The cell lineage of human NK and K cells is controversial. Many previous studies have suggested a relationship between NK cells and T cells (1,2).

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