By Miruna Canagaratnam, David Shaw
A revision booklet within the One cease document revision sequence which covers the foremost proof for the metabolism and meals module within the type of brief resolution Questions, (clinical circumstances) a number of selection Questions and prolonged Matching Questions. Illustrated with easy, simply reproduced line diagrams, this booklet will supply the entire priceless info for examination good fortune.
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Extra resources for One Stop Doc Metabolism & Nutrition
All the amino acids except leucine, lysine, phenylalanine, tyrosine and isoleucine are glucogenic. They are converted to α-ketoacids which can be converted to oxaloacetate and then to phosphoenolpyruvate, which is an intermediate of the gluconeogenic pathway. FA cannot be used for gluconeogenesis. FAs are broken down by β-oxidation which results in acetyl CoA production, and this cannot be converted into any three-carbon or four-carbon compounds in the human liver, as the pyruvate dehydrogenase reaction is irreversible.
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The other 10 ‘non essential’ amino acids can be synthesized from commonly available intermediates. In humans, the dietary essential amino acids are: valine, methionine, histidine, leucine, phenylalanine, lysine, isoleucine, tryptophan, threonine and arginine (arginine and histidine are probably only essential in children and during convalescence). The list can be remembered easily by the ‘memory jogger’ rhyme: Very Many Hairy Little Pigs Live In The Torrid Argentine. PKU is an inherited disorder of amino acid metabolism, with an incidence of 1 in 11000 live births in the UK, and thus is relatively common.