Download One Stop Doc Metabolism & Nutrition by Miruna Canagaratnam, David Shaw PDF

By Miruna Canagaratnam, David Shaw

A revision booklet within the One cease document revision sequence which covers the foremost proof for the metabolism and meals module within the type of brief resolution Questions, (clinical circumstances) a number of selection Questions and prolonged Matching Questions. Illustrated with easy, simply reproduced line diagrams, this booklet will supply the entire priceless info for examination good fortune.

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All the amino acids except leucine, lysine, phenylalanine, tyrosine and isoleucine are glucogenic. They are converted to α-ketoacids which can be converted to oxaloacetate and then to phosphoenolpyruvate, which is an intermediate of the gluconeogenic pathway. FA cannot be used for gluconeogenesis. FAs are broken down by β-oxidation which results in acetyl CoA production, and this cannot be converted into any three-carbon or four-carbon compounds in the human liver, as the pyruvate dehydrogenase reaction is irreversible.

C. d. e.

The other 10 ‘non essential’ amino acids can be synthesized from commonly available intermediates. In humans, the dietary essential amino acids are: valine, methionine, histidine, leucine, phenylalanine, lysine, isoleucine, tryptophan, threonine and arginine (arginine and histidine are probably only essential in children and during convalescence). The list can be remembered easily by the ‘memory jogger’ rhyme: Very Many Hairy Little Pigs Live In The Torrid Argentine. PKU is an inherited disorder of amino acid metabolism, with an incidence of 1 in 11000 live births in the UK, and thus is relatively common.

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