Download Osteoporosis in Older Persons: Pathophysiology and by Gustavo Duque PDF

By Gustavo Duque

The booklet summarizes fresh advances within the elucidation of the mechanisms occupied with senile osteoporosis in addition to its strength therapy, bringing an built-in technique from the bench to the scientific perform. a distinct point of this booklet is its emphasis at the program of translational study within the box of osteoporosis and falls. The publication offers a whole assessment at the prevention in addition to present and destiny remedies of osteoporosis.

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Extra resources for Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach

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Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann N Y Acad Sci 2006;1068:173–179. Seeman E. Estrogen, androgen, and the pathogenesis of bone fragility in women and men. Curr Osteoporos Rep 2004;2:90–96. Jessop HL, Sjoberg M, Cheng MZ, et al. Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. J Bone Miner Res 2001;16: 1045–1055. Zaman G, Jessop HL, Muzylak M, et al. Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen.

BMP signaling and skeletogenesis. Ann N Y Acad Sci 2006;1068:26–40. Zaidi SK, Sullivan AJ, van Wijnen AJ, et al. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A 2002;99:8048–8053. Afzal F, Pratap J, Ito K, et al. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 2005;204:63–72. Lee MH, Kim YJ, Kim HJ, et al. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGFbeta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.

87. Ohnaka K, Taniguchi H, Kawate H, et al. Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Commun 2004;318:259–264. 88. Ohnaka K, Tanabe M, Kawate H, et al. Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem Biophys Res Commun 2005;329:177–181. 89. Bassett JH, Williams GR. The molecular actions of thyroid hormone in bone. Trends Endocrinol Metab 2003;14:356–364.

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