By Gustavo Duque
The booklet summarizes fresh advances within the elucidation of the mechanisms occupied with senile osteoporosis in addition to its strength therapy, bringing an built-in technique from the bench to the scientific perform. a distinct point of this booklet is its emphasis at the program of translational study within the box of osteoporosis and falls. The publication offers a whole assessment at the prevention in addition to present and destiny remedies of osteoporosis.
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Extra resources for Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach
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BMP signaling and skeletogenesis. Ann N Y Acad Sci 2006;1068:26–40. Zaidi SK, Sullivan AJ, van Wijnen AJ, et al. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A 2002;99:8048–8053. Afzal F, Pratap J, Ito K, et al. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 2005;204:63–72. Lee MH, Kim YJ, Kim HJ, et al. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGFbeta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.
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