Download Parkinson's disease : genetics and pathogenesis by Ted M. Dawson PDF

By Ted M. Dawson

An authoritative choice of fresh breakthroughs in Parkinson's affliction (PD) examine, Parkinson’s ailment: Genetics and Pathogenesis spans key findings at the mechanisms of neurodegeneration and the function of particular genes which may result in greater cures for PD. The booklet experiences the foremost points of the ailment together with motoric and pathologic positive aspects, autonomic disorder, sleep issues, and neuropsychiatric manifestations. It additionally offers an in-depth assessment of genetic concerns. With contributions by means of well-known specialists at the subject, emphasis is put on pathogenesis, experimental types, destiny healing possibilities, and examine tendencies affecting the field.

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Environmental and genetic risk factors in Parkinson’s disease: a case-control study in southern Italy. Mov Disord 1996; 11(1):17–23. 9. Elbaz A, Grigoletto F, Baldereschi M, et al. Familial aggregation of Parkinson’s disease: a population-based case-control study in Europe. EUROPARKINSON Study Group. Neurology 1999; 52(9):1876–1882. Genetics of Parkinson’s Disease 29 10. Marder K, Levy G, Louis ED, et al. Familial aggregation of early- and late-onset Parkinson’s disease. Ann Neurol 2003; 54(4):507–513.

This fourfold discrepancy may, in part, reflect age distribution differences among these populations, as well as variation in case definition and diagnostic criteria, rather than a true difference in disease frequency. Some studies used medical records alone to diagnose parkinsonism (3) and, therefore, may have included persons with other disorders. For example, a study performed in Finland initially identified 775 patients as having PD after a review of their medical records, but, when examined, 201 of these individuals were diagnosed with essential tremor (8).

12. Ward CD, Duvoisin RC, Ince SE, et al. Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology 1983; 33(7):815–824. 13. Marsden CD. Parkinson’s disease in twins. J Neurol Neurosurg Psychiatry 1987; 50(1):105–106. 14. Marttila RJ, Kaprio J, Koskenvuo M, et al. Parkinson’s disease in a nationwide twin cohort. Neurology 1988; 38(8):1217–1219. 15. Vieregge P, Schiffke KA, Friedrich HJ, et al. Parkinson’s disease in twins. Neurology 1992; 42(8):1453–1461. 16. Tanner CM, Ottman R, Goldman SM, et al.

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