Download Pediatric Bone Sarcomas: Epiphysiolysis before excision by Luis Sierrasesúmaga-Ariznabarreta, Moira Garraus (auth.), PDF

By Luis Sierrasesúmaga-Ariznabarreta, Moira Garraus (auth.), Mikel San-Julian, José Cañadell (eds.)

Pediatric Bone Sarcomas: Epiphysiolysis prior to excision addresses malignant bone tumours through focusing upon physeal distraction (epiphysiolysis) earlier than excision. this system has lengthy been utilized by the authors of this e-book in keeping the joint in metaphyseal bone tumours in childrens. they're to that end now sharing their wisdom and event with all these within the box of orthopedic surgery.

In the final 30 years, the end result for sufferers plagued by malignant bone tumours has more advantageous dramatically. higher wisdom of the illness, enhanced imaging equipment, new surgical suggestions and especially the arrival of chemotherapy have led to expanding good fortune during this box.

Preserving the lifetime of those sufferers 30 years in the past used to be the single goal of physicians. Now, survival charges have elevated and the recent demanding situations posed to the doctor are on retaining the limb and its functionality, while keeping off problems. 30 years in the past joint maintenance as regards to the bone tumour was once exceptional. extra lately, this can be a hope and attainable consequence universal to everybody who treats those patients.

Targeted basically in the direction of orthopedic surgeons and pediatric oncologists this booklet may also be of curiosity to all these within the fields of orthopedics, oncology, pediatrics and surgery.

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Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A. 1993;90:5752–5756. 67. Lessnick SL, Braun BS, Denny CT, May WA. Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene. 1995;10:423–431. 68. Janknecht R, Nordheim A. Gene regulation by Ets proteins. Biochim Biophys Acta. 1993; 1155:346–356. 69. Huang HY, Illei PB, Zhao Z, et al. Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse.

2005;23:1483–1490. 14. Belchis DA, Gocke CD, Geradts J. Alterations in the rb, p16, and cyclin d1 cell cycle control pathway in osteosarcomas. Pediat Pathol Mol Med. 2000;19:377–389. 15. Yamaguchi T, Toguchida J, Yamamuro T, et al. Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. Cancer Res. 1992;52:2419–2423. 16. Wadayama B, Feugeas O, Guriec N, et al. Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J Clin Oncol.

2002;20:441–451. 100. Dauphinot L, De Oliveira C, Melot T, et al. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. Oncogene. 2001;20:3258–3265. 101. Bailly RA, Bosselut R, Zucman J, et al. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol. 1994;14:3230–3241. 102. Takahashi A, Higashino F, Aoyagi M, et al. EWS/ETS fusions activate telomerase in Ewing’s tumors.

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