Download Platelet Proteomics: Principles, Analysis, and Applications by Ángel García-Alonso, Yotis Senis PDF

By Ángel García-Alonso, Yotis Senis

The aim of the e-book is to introduce platelets, and their sensible position in thrombotic and heart problems, justifying the relevance of platelet proteomics examine. concentration then shifts to the hot advancements on mass spectrometry (MS)-based proteomics.  This bankruptcy exhibits strength functions for platelet proteomics now not but carried out.  It comprises examples of post-translational transformations (PTMs) research in platelets.

The moment a part of the e-book makes a speciality of the most learn performed thus far on platelet proteomics. This contains basic proteome mapping by way of non-gel established separation tools (MudPit), research of the overall platelet proteome and signaling cascades through gel-based separation equipment (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). ultimately, the final part hyperlinks the platelet transcriptome and alertness to disease.  This part is very proper and comprises chapters on proteomics, transcriptomics, sensible genomics, platforms biology, and their functions to platelet-related diseases.

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Orbitrap Analyzers. Orbitrap mass analyzers have gained attention since the newly introduced instrumentation detects at high resolution and allows mass accuracies in the sub-part-per-million (

Because of their anucleate nature, platelets show very limited de novo protein synthesis and for this reason are well-suited model systems for proteome analysis. Originally, platelet proteomics studies focused on two-dimensional gel electrophoresis in combination with matrix-assisted laser desorption/ionization–mass spectrometry (MALDI-MS), yet with the introduction of new and improved methods, a variety of proteomic strategies have been applied to address distinct biological questions. In this chapter we will summarize the field of platelet proteomics with a special emphasis on posttranslational modifications.

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