Download Production, Concentration and Metabolism During Pregnancy. by F. A. Kincl, J. R. Pasqualini PDF

By F. A. Kincl, J. R. Pasqualini

Written by way of the world's best researchers in steroid biochemistry this quantity describes the ways that hormonal focus is regulated while pregnant. it's a finished account of ways biosynthesis, metabolism and inter-compartmental delivery are on the topic of the focus of every hormone present in placental, fetal and maternal booths. there's additionally an introductory bankruptcy on hormonal mechanism of motion

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1 9 6 8 ) . , 1 9 5 8 ) , b u t a t p r e s e n t , n o p h y s i o l o g i c a l role h a s b e e n f o u n d i n t h e h u m a n . T h e c o n c e n t r a t i o n of 5 a - p r e g n a n e d i o n e (5a-dihydroprogesterone) d u r i n g t h e follicular p h a s e is a r o u n d 5 t i m e s h i g h e r t h a n t h a t of p r o g e s t e r o n e , b u t d u r i n g t h e l u t e a l p h a s e , t h e v a l u e d e c r e a s e s t o 1 / 5 to 1 \1 of t h e p r o g e s t e r o n e c o n c e n t r a t i o n ( F i g .

11. A Simplified Diagram Showing Ovarian Steroidogenesis The biosynthesis of ovarian hormones proceeds from acetate through a number of steps. Only the major pathways and principal steps are outlined. H u m a n a n d b o v i n e o v a r i a n tissues a r e c a p a b l e of s u l f u r y l a t i n g d e h y d r o e p i a n d r o s t e r o n e a n d e s t r a d i o l , respectively. T h e h u m a n o v a r y is also c a p a b l e of h y d r o l y s i n g d e h y d r o e p i a n d r o s t e r o n e sulfate.

H o r m o n a l Mechanisms in Reproduction DOPAMINE OH ι OH OHv^^cH-CH 2-NH a O H ^ X 45 0 OH " 2-HYDROXY ESTRADIOL MOREPINEPHRINE CATECHOL-0-METHYL-TRANSFERASE 2-METHOXYESTRADIOL 2-METHOXYNOREPINEPHRINE Fig. 29. Structural Correlation Between Catecholamines and Catechol Estrogens Catechol-O-methyl transferase is involved in the metabolism of both norepinephrine and 2-hydroxyestradiol. 5. Androgens T h e most a b u n d a n t circulating androgens are: androstenedione, testosterone, 5a-dihydrotestost e r o n e , d e h y d r o e p i a n d r o s t e r o n e a n d d e h y d r o e p i a n d r o s t e r o n e sulfate.

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