By F. A. Kincl, J. R. Pasqualini
Written by way of the world's best researchers in steroid biochemistry this quantity describes the ways that hormonal focus is regulated while pregnant. it's a finished account of ways biosynthesis, metabolism and inter-compartmental delivery are on the topic of the focus of every hormone present in placental, fetal and maternal booths. there's additionally an introductory bankruptcy on hormonal mechanism of motion
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Extra info for Production, Concentration and Metabolism During Pregnancy. Production, Concentration & Metabolism During Pregnancy
1 9 6 8 ) . , 1 9 5 8 ) , b u t a t p r e s e n t , n o p h y s i o l o g i c a l role h a s b e e n f o u n d i n t h e h u m a n . T h e c o n c e n t r a t i o n of 5 a - p r e g n a n e d i o n e (5a-dihydroprogesterone) d u r i n g t h e follicular p h a s e is a r o u n d 5 t i m e s h i g h e r t h a n t h a t of p r o g e s t e r o n e , b u t d u r i n g t h e l u t e a l p h a s e , t h e v a l u e d e c r e a s e s t o 1 / 5 to 1 \1 of t h e p r o g e s t e r o n e c o n c e n t r a t i o n ( F i g .
11. A Simplified Diagram Showing Ovarian Steroidogenesis The biosynthesis of ovarian hormones proceeds from acetate through a number of steps. Only the major pathways and principal steps are outlined. H u m a n a n d b o v i n e o v a r i a n tissues a r e c a p a b l e of s u l f u r y l a t i n g d e h y d r o e p i a n d r o s t e r o n e a n d e s t r a d i o l , respectively. T h e h u m a n o v a r y is also c a p a b l e of h y d r o l y s i n g d e h y d r o e p i a n d r o s t e r o n e sulfate.
H o r m o n a l Mechanisms in Reproduction DOPAMINE OH ι OH OHv^^cH-CH 2-NH a O H ^ X 45 0 OH " 2-HYDROXY ESTRADIOL MOREPINEPHRINE CATECHOL-0-METHYL-TRANSFERASE 2-METHOXYESTRADIOL 2-METHOXYNOREPINEPHRINE Fig. 29. Structural Correlation Between Catecholamines and Catechol Estrogens Catechol-O-methyl transferase is involved in the metabolism of both norepinephrine and 2-hydroxyestradiol. 5. Androgens T h e most a b u n d a n t circulating androgens are: androstenedione, testosterone, 5a-dihydrotestost e r o n e , d e h y d r o e p i a n d r o s t e r o n e a n d d e h y d r o e p i a n d r o s t e r o n e sulfate.