Download Retinoblastoma - A Bibliography and Dictionary for by Philip M. Parker PDF

By Philip M. Parker

In March 2001, the nationwide Institutes of overall healthiness issued the subsequent caution: "The variety of websites providing health-related assets grows on a daily basis. Many websites supply beneficial info, whereas others can have info that's unreliable or misleading." moreover, as a result fast elevate in Internet-based details, many hours could be wasted looking out, settling on, and printing. in view that in basic terms the smallest fraction of data facing retinoblastoma is listed in se's, resembling www.google.com or others, a non-systematic method of web examine might be not just time eating, but in addition incomplete. This e-book was once created for doctors, scholars, and individuals of most of the people who are looking to behavior clinical examine utilizing the main complex instruments to be had and spending the smallest amount of time doing so.

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Extra info for Retinoblastoma - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers

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Based on these preliminary results, we plan to address the role of Heclp during chromosome segregation in mammalian cells and to explore the possibility of using the Heclp network as a target for developing small molecules that inactivate its function as potential therapeutic candidates. In this application, we proposed four specific aims to address these issues: Aim 1: To elucidate the biological significance of the interaction between Hec 1 and Hint 1 at kinetochores and to analyze the role of Heclp and Hintl in spindle checkpoint response.

Intriguingly, the expression of HEC 1 is highly elevated in most cancer cell lines. Based on these preliminary results, we plan to address the role of Heclp during chromosome segregation in mammalian cells and to explore the possibility of using the Heclp network as a target for developing small molecules that inactivate its function as potential therapeutic candidates. In this application, we proposed four specific aims to address these issues: Aim 1: To elucidate the biological significance of the interaction between Hec 1 and Hint 1 at kinetochores and to analyze the role of Heclp and Hintl in spindle checkpoint response.

Center for Cancer Research; Massachusetts Institute of Technology 77 Massachusetts Ave Cambridge, Ma 02139 Timing: Fiscal Year 2006; Project Start 01-APR-1997; Project End 31-MAR-2011 Summary: (provided by applicant): The human retinoblastoma gene (RB-1) is a wellestablished tumor suppressor. Somatic RB-1 inactivation is observed in approximately one third of all human tumors. Individuals carrying germline RB-1 mutations develop retinoblastoma with near complete penetrance and they are also highly predisposed to develop osteosarcomas.

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