By Robert J. Alpern, Michael J. Caplan, Orson W. Moe
A vintage nephrology reference for over 25 years, Seldin & Giebisch's The Kidney, is the said authority on renal body structure and pathophysiology. during this fifth variation, such new and strong disciplines as genetics and telephone biology were deployed to deepen and widen additional the explanatory framework. not just have prior chapters been greatly up-to-date, yet new chapters were additional to incorporate extra disciplines. person chapters, for instance, now supply distinctive remedy of the importance of cilia; the function of stem cells is now given designated attention. eventually, there was an important enlargement of the portion of pathophysiology, incorporating the more recent findings of phone biology and genetics. should you examine the advance of ordinary renal functionality or the mechanisms underlying renal disorder, Seldin & Giebisch's The Kidney is your number 1 resource for info. deals the main accomplished insurance out there of fluid and electrolyte rules and dysregulation in eighty five thoroughly revised chapters and 10 new chapters.Includes 4sections, sixty two chapters, dedicated to law and problems of acid-base homeostasis, and epithelial and nonepithelial delivery rules. comprises foreword via Donald Seldin and Gerhard Giebisch, global popular names in nephrology and editors of the former 3 editions. Read more...
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Additional resources for Seldin and Giebisch's the kidney : physiology & pathophysiology
12 While these morphological features were originally believed to have a structural basis, there is now evidence that they may be fixation artifacts. 130 Laminins consist of large (B400À800 kDa) heterotrimeric secreted glycoproteins. In mammals, five α-, three β-, and three γ-subunits have been identified in at least 15 different heterotrimeric complexes. 130 Typically, the amino-termini of each subunit consist of a globular LN or polymer domain that is involved in basement membrane assembly. The carboxy-terminus of the α-subunit is folded into a series of five globular domains (G1À5) that are essential for binding to the cell surface.
This system thus provides investigators with simultaneous and independent access to both plasmalemmal domains. for physiological studies, but later turned out to also be very useful for biochemical and morphological experiments. 4 μm that form the bottom cup. 4). Cells are plated on the upper surface of the filter. When a confluent monolayer is formed, it effectively creates a barrier between media compartments. 4). As epithelial cells in the kidney and other organs would normally receive most of their nutrition from the basolateral (serosal) surface, permeable supports are, in a sense, a more natural growth environment than impermeable tissue culture plastic or glass.
A large number of studies have subsequently elucidated the sorting of many endogenous MDCK cell proteins, as well as exogenous proteins expressed from vectors. This system remains the most thoroughly investigated paradigm and, as will be detailed below, has yielded important insights into the nature of pathways and signals that participate in membrane protein targeting and the overall biogenesis of epithelial polarity. 167À170 For example, immortalization genes from human papillomavirus or a hybrid between adenovirus and SV40 have been used to create permanent cell lines from human proximal tubule cells.