Download Viral Genome Packaging: Genetics, Structure, and Mechanism by Carlos E. (Ed.) Catalano, Carlos E. Catalano PDF

By Carlos E. (Ed.) Catalano, Carlos E. Catalano

Viral Genome Packaging  focuses at the means of genome ''packaging'' inside of a pre-formed viral procapsid. The chapters of this book concentrate at the biochemistry, enzymology and structural elements of the genome packaging equipment. This book defines a large mechanistic foundation for the method around the prokaryotic and eukaryotic border, and for DNA and RNA viruses. The biochemical, biophysical and structural facets of genome packaging are tested intimately.

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58. Friedman D. Integration host factor: A protein for all reasons. Cell 1988; 55:545-549. 59. Xin W, Cai Z-H, Feiss M. Function of IHF in X DNA packaging. II. Effects of mutations altering the IHF binding site and the intrinsic bend in cosB on X development. J Mol Biol 1993; 230:505-515. 60. Hwang Y, Feiss M. A defined system for in vitro lambda DNA packaging. Virology 1995; 211(2):367-76. 61. Yang Q, Catalano C. Biochemical characterization of bacteriophage lambda genome packaging in vitro. Virology 2003; 305:276-287.

J Mol Biol 2 0 0 1 ; 314:411-421. 80. Gorbalenya A, Koonin E. Curr Opin Struct Biol 1993; 3:419-429. 8 1 . Story R, Li H , Abelson J. Crystal structure of a D E A D box protein from the hyperthermophile Methanococcus jannaschii. Proc Natl Acad Sci USA 2 0 0 1 ; 98:14650-1470. 82. Yang Q , Catalano C. A minimal kinetic model for a viral D N A packaging machine. Biochemistry 2004; 43:289-299. 83. H a n g J, Catalano C, Feiss M . T h e functional asymmetry of cosN, the nicking site for bacteriophage A, D N A packaging, is dependent on the terminase binding site, cosB.

Bacteriophage Lambda Terminase and the Mechanism of Viral DNA Packaging 27 Pre-Translocatfon Strand-Separation Complex Activated Nicking Complex jj _ \ ^ complex gpFi cleavage T*Dcos ^'"^ »- Procapsid {in vitro) strand separation f T«OR*DI. * •• » (T*DR)(T*DL) ATP {Tenntnase] DR^DL Ligase Nicked, atih0at0d duplex T*DR Complex I gpR® Terminase plus Dt Figure 10. Model for gpFI and Procapsids in die roj-Cleavage Reaction. Details are described in the text. For concatemer processing by these phages, an initial cut is made at a defined site called pac.

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